GnRH pulses and gonadotropin secretion A pattern of pulsatile gonadotropin-releasing hormone (GnRH) secretion is required to sustain gonadotropin synthesis and secretion. The frequency and amplitude of GnRH pulses deter- mine the expression and secretion of pituitary luteinizing

The ovarian aging, a dynamic process that precedes the clinical manifestations of menopause, can be assessed using ovarian reserve biomarkers. It is well-known that reproduction during the later years of reproductive life has known limitations that challenge the success of assisted reproduction. Therefore, a review of the neuroendocrine modifications during this critical period of reproductive life may help to elucidate the ovarian aging process and its impact on reproduction. In this review, we aim to further the discussion of neuroendocrine changes taking place during the ovarian aging process that may impact reproductive function.